Process for the production of immobilized antibodies

Details Process for the production of immobilized antibodies Process for the production of immobilized antibodies

1990-03-22

1992-04-14

Schofer, Joseph L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

435177, 435180, 530402, 530405, 530810, 530812, 530817, C08G 6391

Patent

active

051049317

ABSTRACT:
A single-step procedure for the immobilization of antibodies, comprising reacting a purified antibody with buffered periodate in an amount sufficient to produce aldehyde groups in the presence of a polymer carrier material which has been modified with adipic acid dihydrazide is disclosed. The present invention provides dramatic improvements in activity. and yield of immobilized antibody over the prior multi-step procedure employing separate oxidation and immobilization steps.

REFERENCES:
patent: 4948836 (1990-08-01), Solomon et al.
Gideon Fleminger et al, Oriented Immobilization of Periodate-Oxidized Monoclonal Antibodies on Amino and Hydrazide Derivatives of Eupergit C, Applied Biochemistry and Biotechnology, vol. 23, 1990, pp. 123-136.
Gideon Fleminger et al, Single Step Oxidative Binding of Antibodies to Hydrazide-Modified Eupergit C, Applied Biochemistry and Biotechnology, 1990, pp. 231-238.

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