Process for the production of hydroxymethylimidazoles

Details Process for the production of hydroxymethylimidazoles Process for the production of hydroxymethylimidazoles

1980-06-05

1981-09-29

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548343, C07D23364

Patent

active

042924316

ABSTRACT:
This invention discloses a process for the production of hydroxymethylimidazoles which comprises reacting imidazolecarboxylic acids, their esters or inorganic salts with a formaldehyde agent in the presence of an alkali in an aqueous medium.

REFERENCES:
patent: 2946804 (1960-07-01), Zaugg et al.
patent: 4063023 (1977-12-01), Anderson et al.
patent: 4104473 (1978-08-01), Sawa et al.
Jones, R., et al., J. Am. Chem. Soc., 71, 2444 (1949).
Walker, J., Formaldehyde, 3rd Ed., Reinhold Pub. Corp., NY, 1964, p. 218.
Theilheimer, W., Synthetic Methods of Organic Chemistry, vol. 8, Interscience, NY, 1954, p. 21.
Mole, T., J. Chem. Soc., 2132 (1960).
House, H., Modern Synthetic Reactions, W. A. Benjamin, Inc., NY, 1965, pp. 26, 27 and 34.
Morrison, R., et al., Organic Chemistry, 3rd Ed., Allyn and Bacon, Boston, 1973, p. 709.

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