Process for the production of human tissue plasminogen activator

Details Process for the production of human tissue plasminogen activator Process for the production of human tissue plasminogen activator

1988-07-15

1992-08-18

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4352402, 435 692, C12P 2102

Patent

active

051399393

ABSTRACT:
Human tissue plasminogen activator is produced by culturing a human rhabdomyosarcoma-derived cell, KYM-SF, in a medium, followed by purification of single-chain and/or double-chain human tissue plasminogen activator from the medium.

REFERENCES:
patent: 4757005 (1988-07-01), Chan
Chemical Abstracts, vol. 104, No. 17, Apr. 1986, p. 548, Abstract No. 147145a, Columbus, Ohio, US; & JP-A-60 231 611 (Meiji Jilk Products Co., . . .
Chemical Abstracts, vol. 108, No. 11, Mar. 1988, p. 534, Abstract No. 93083r, Columbus, Ohio, US; & JP-A-62 158 219 (Meiji Milk Products Co., . . .
Matsuo et al. Chem. Abstracts vol. 102 1985 Abstract #76954j.
Sekiguchi et al. Biomedicine & Pharmaco Therapy 1985 39, 372-380.

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