Process for the production of human erythropoietin

Details Process for the production of human erythropoietin Process for the production of human erythropoietin

1981-08-10

1983-03-22

Schain, Howard E.

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Expanding device for textile webs

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424 88, 424 99, 424 95, 424103, 424105, 435 68, 435172, 435240, 435848, A61K 3724, C07G 700

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043775136

ABSTRACT:
The present invention relates to a process for the production of human erythropoietin.
More precisely, the invention relates to a process for the mass production of human erythropoietin, comprising in vivo multiplication of human lymphoblastoid cells capable of producing human erythropoietin, and human erythropoietin production by the multiplied human lymphoblastoid cells.
The human erythropoietin production according to the present invention is much higher, in terms of human erythropoietin production per cell, than that attained by conventional processes using in vitro tissue culture; thus, human erythropoietin can be used in a sufficient amount for the prevention and treatment of human diseases.

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patent: 4328207 (1982-05-01), Sugimoto
Chemical Abstracts, 91:86930s (1979).
Miyake, T., et al, "Purification of Human Erythropoietin", The Journal of Biological Chemistry, 252, No. 15, pp. 5558-5564 (1977).
Nature, 1961, p. 75, Lowy et al.
Clinica Chimica Acta 13 (1966), pp. 491-497, Lowy et al.
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Chem. Abstracts, vol. 61, 1964, 10920c, Winkert et al.
Chem. Abstracts, vol. 74, 1971, 49756t, Zivny et al.

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