Process for the production of epothilones and intermediate produ

Details Process for the production of epothilones and intermediate produ Process for the production of epothilones and intermediate produ

1997-09-02

1999-10-19

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548204, C07D27722

Patent

active

059691450

ABSTRACT:
The invention relates to a process for the production of epothilones and intermediate products within the process.
Epothilones A and B are natural substances, which can be produced by microorganisms, and the taxols have similar properties and are thus of particular interest in pharmaceutical chemistry.

REFERENCES:
Grubbs, R.H. et al., Acc.Chem.Res., vol. 28, pp. 446-452 (1995).
Gerth, K. et al., J. Antibiot., vol. 49, No. 6, pp. 560-563 (1996).
Bollag, M.D. et al., Cancer Res., vol. 55, pp. 2325-2333 (1995).
Meyers, A.I. et al., J.Org.Chem., vol. 38, No. 12, pp. 2136-2143 (1973).
Keller-Schierlein, W. et al., Helv.Chim.Acta, vol. 66, pp. 1253-1261 (1983).
Nerdel, F. et al., Chem.Ber., vol. 100, pp. 720-735 (1967).
Balog, A. et al., Angew.Chem.Int.Ed.Engl., vol. 35, No. 23/24, pp. 2801-2803 (1997).
Meng, D. et al., J.Am.Chem.Soc., vol. 119, No. 11, pp. 2733-2734 (1997).
Taylor R.E. et al., Tetrahedron Lett., vol. 38, No. 12, pp. 2061-2064 (1997).
Yang. Z. et al., Angew.Chem.Int.Ed.Engl., vol. 36, No. 1/2,, pp. 166-168 (1997).
Blechert, S. et al., Liebigs Ann.Chem., pp. 2135-2140 (1996).
Meng, D. et al., J.Org.Chem., vol. 61, No. 23, pp. 7998-7999 (1996).
Bertinato, P. et al., J.Org.Chem. vol. 61, No. 23, pp. 8000-8001 (1996).
Nicolaou, K.C. et al., Angew.Chem.Int.Ed.Engl., vol. 35, No. 20, pp. 2399-2401 (1996).
Meng et al., J. Am. Chem. Society, vol. 119, pp. 10073-10092 (1997).
Nicolaou et al., Nature, vol. 387, pp. 268-272 (1997).
Nicolaou et al., J. Am. Chem. Soc., vol. 119, pp. 7974-7991 (1997).
Balog et al., Tetrahedron Lett., vol. 38, No. 26, pp. 4529-4532 (1997).
Su et al., Angew. Chem. Int. Ed. Engl., vol. 36, No. 19, pp. 2093-2096 (1997).
Meng et al., J. Am. Chem. Soc., vol. 119, pp. 2733-2734 (1997).

Affiliated with

Also associated with

Rating

Process for the production of epothilones and intermediate produ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of epothilones and intermediate produ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of epothilones and intermediate produ will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2057194