Process for the production of endotropine

Details Process for the production of endotropine Process for the production of endotropine

1998-06-04

1999-12-21

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45106

Patent

active

060051108

ABSTRACT:
A process for the production of endotropine by catalytically reducing tropanone with hydrogen with Raney nickel or Raney copper. This process is conducted with tropanone in an aqueous solution absent of organic solvents, in a closed system, at atmospheric pressure and ambient temperature and subject to turbulent action at 1000 to 1500 r.p.m. The process leads to average yields of 94%. The process improves on prior art processes which use an overpressure and organic solvents which involve a high fire and explosion risk.

REFERENCES:
patent: 2366760 (1945-01-01), Van De Kamp et al.
patent: 2746976 (1956-05-01), Stoll et al.
Chemical Abstracts, vol. 99, No. 15, Abstract 99:122721a; Kollas, Laszlo, et al "Stereoselective Reduction of Nortropinones with a Homogeneous Catalyst", Oct. 10, 1983.
Chemical Abstracts, vol. 93, No. 13, Abstract 93:132665a; Maksudov, A.M., et al "Tropine Preparation Method", Sep. 29, 1980.
Chemical Abstracts, vol. 97, No. 23, Abstract 97:198428q; Chou Ta Shue "Stereoselective Preparation of Tropine"; Dec. 6, 1982.
Chemical Abstracts, vol. 83, No. 23, Abstract 19351d; Jain, M.P., et al "Modified Process for the Synthesis of Tropine", Dec. 8, 1975.

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