Process for the production of DTPA-bis anhydride

Details Process for the production of DTPA-bis anhydride Process for the production of DTPA-bis anhydride

2004-12-16

2009-06-02

Hartley, Michael G (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

Reexamination Certificate

active

07541019

ABSTRACT:
Process for the production of DTPA-bis(anhydride) by reacting DTPA with acetic anhydride in pyridine under elevated temperature wherein the molar amount of pyridine is equal to or less than 6 times the molar amount of DTPA.

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patent: 272584 (1991-11-01), None
patent: 0183760 (1986-06-01), None
Miyamoto, M. et al., “Design and Preparation of Gadolinium-Reservoir Microcapsules for Neutron-Capture Therapy by Meanse of the Wurster Process” Chemical and Pharmaceutical Bulletin, Phar. Society of Japan, Tokyo, JP, vol. 45, No. 12 Dec. 1997, pp. 2043-2050.
Eckelman, W.C., et al., “New Compounds: Fatty Acid and Long Chain Hydrocarbon Derivatives Containing a Strong Chelating Agent” Journal of Pharmaceutical Sciences, American Pharmaceutical Assoc. Wash. US, vol. 64, No. 4 Apr. 1975, pp. 704-706.
PCT/NO2004/000389 Int'l Search report/written opinion dated May 2005.

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