Process for the production of dry pharmaceutical forms and the t

Details Process for the production of dry pharmaceutical forms and the t Process for the production of dry pharmaceutical forms and the t

1996-06-27

1998-07-07

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

514952, 514963, A61K 966

Patent

active

057764956

ABSTRACT:
A process for the production of a solid dispersion of at least one therapeutic agent in a hydrophilic carrier having enhanced solubility in an aqueous media comprising dissolving at least one therapeutic agent in a volatile organic solvent containing a very hydrophilic polymer and evaporating the solvent to dryness to form a co-precipitate of therapeutic agent and hydrophilic polymer and the resulting products and their therapeutic method of use.

REFERENCES:
Chiou, W.L. and Riegelman, S.: Pharmaceutical applications of Solid Dispersion Systems. J. of Pharmaceutical Sciences. vol. 60, pp. 1281-1302, 1971.
Kassem, M.A.A. et al.: High Energy States of Tolnaftate. Egypt. J. Pharm. Sci. vol. 33, pp. 267-281, 1992.

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