Process for the production of disaccharide-tripeptide and disacc

Details Process for the production of disaccharide-tripeptide and disacc Process for the production of disaccharide-tripeptide and disacc

1983-01-04

1985-05-07

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 70, 435212, 435220, C12P 2102, C12P 2106, C12N 948, C12N 952

Patent

active

045158916

ABSTRACT:
Process for the production of a disaccharide-tripeptide and disaccharide-tetrapeptide which comprises applying an endo-N-acetylmuramidase from Streptomyces globisporus and a D-alanyl-meso-2,6-diaminopimelic acid endopeptidase from Streptomyces nitrosporeus SK (FERM BP-216) or Streptomyces globisporus to hydrolyze cell walls of bacteria such as Lactobacillus plantarum and Corynebacterium diphtheriae. Said process can give the desired disaccharide-tripeptide and disaccharide-tetrapeptide having excellent pharmacological activities such as immunostimulant activity and potentiating activity of nonspecific resistance to bacterial infections in the form of a single compound (i.e. not mixture thereof) in a high yield.

REFERENCES:
patent: 3929579 (1975-12-01), Yoshimura et al.
patent: 4186194 (1980-01-01), Adam et al.
Experientia, vol. 32, pp. 677-683 (1976).
Biken Journal, vol. 19, pp. 75-91 (1976).
Agr. Biol. Chem. 39(8), pp. 1533-1543 (1975).

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