Process for the production of dihydroxypropyltheophylline

Details Process for the production of dihydroxypropyltheophylline Process for the production of dihydroxypropyltheophylline

1982-06-14

1983-09-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

424253, C07D47308

Patent

active

044057830

ABSTRACT:
Pure hydroxypropyltheophylline is produced by the catalytic reaction of theophylline with glycidol in the presence of a hydroxide of a short chain alcoholate of an alkali metal or an alkali metal salt of a pseudohydrohalic acid which has a readily polarizable anion. The catalyst is suitably employed in an amount between 0.01 and 0.2 moles per mole of theophylline. The dihydroxypropyltheophylline is obtained directly in the reaction in a high purity.

REFERENCES:
patent: 2575344 (1951-11-01), Jones et al.
patent: 4031218 (1977-06-01), El-Antably
Maney, J. American Pharm. Assoc. vol. 35, pp. 266-272 (1946).
Samejima, Yakugarku Zasski vol. 80, pp. 1706-1723 (1960).
Chem. Abst. vol. 54, 11648g-11649.
Chem. Abst. vol. 55, 10439i.
Ishay, J. Chem. Soc. (London) 1956 (3975).
Auslander, Sci. Pharm. Proc. 25th-(1966) pp. 75-77.
Roth, Archiv der Pharmazie 292/64234 (1939).

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