Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1997-04-04
1999-07-13
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435119, 4352521, 435822, C12N 100, C12P 1710, C12P 1718
Patent
active
059225815
ABSTRACT:
A process for producing d-biotin comprises cultivating a microorganism of the genus Kurthia and which is resistant to biotin antimetabolites and capable of producing d-biotin in a medium under aerobic conditions, and separating the resulting d-biotin from the fermentation broth. The cultivation medium suitably contains an assimilable carbon source, a digestible nitrogen source, inorganic salts and other nutrients necessary for the growth of the microorganism at a pH of about 5-9, temperature of about 10-40.degree. C. and for a duration of about 1-10 days. The preferred microorganism are Kurthia sp. 538-KA26, 538-17H4, 538-51F9 and 538-2A 13 (DSM No. 10609, 10608, 10610 and 10607, respectively), which are also new, and as such represent a further aspect of the present invention. The so-produced d-biotin is one of the essential vitamins for the nutrition of animals, plants and microorganisms, and is important as a medicine or food additive. It is produced in particularly high yield by the process of the present invention.
REFERENCES:
CAPLUS Abstract 1984:99663 -100:99663 Shaw et al., "The Vitamin requirements of Kurthia zopfil and Kurthia gibsonii" "Syst. Appl. Microbio." (1983) 4(4), pp. 439-443.
Derwent Abstract No. AN-96-500371 (Abstract of JP 08 256 785A). Published Oct. 8, 1996.
Agric. Biol. Chem., 47(5):1011-1016 (1983).
Bergey's Manual of Systematic Bacteriology, 9th ed., vol. 2, p. 1255 (1984).
Biochem. Biophys. Res. Comm., 18:788 (1965).
J. Microbiological Methods, 6:237-245 (1987).
Proc. Soc. Exp. Biol. Med., 56:95-98 (1944).
Hoshino Tatsuo
Noro Akifumi
Tazoe Masaaki
Ebel Eileen M.
Johnston George W.
Lilling Herbert J.
Roche Vitamins Inc.
Tramaloni Dennis P.
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