Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2008-01-01
2008-01-01
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C252S301160, C252S299010
Reexamination Certificate
active
10344690
ABSTRACT:
A method for preparing a crystal of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid having a single endothermic peak approximately at 233° C. in differential scanning calorimetry, which comprises the step of recrystallizing a crystal of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid from a mixture of water and ethanol. The method enables selective preparation of type-II crystals which are stable against physical impact. The resulting crystals are free from highly toxic hexane as a residual solvent, and preferably used as an active ingredient of pharmaceuticals.
REFERENCES:
patent: 4104297 (1978-08-01), Buxbaum et al.
patent: 4703110 (1987-10-01), Shudo
patent: 5214202 (1993-05-01), Hamada et al.
patent: 0170105 (1986-02-01), None
patent: 0478787 (1992-04-01), None
patent: 61-22047 (1986-01-01), None
patent: 61-76440 (1986-04-01), None
patent: 3001632 (1999-11-01), None
patent: 2000-34262 (2000-02-01), None
patent: 91/14673 (1981-10-01), None
English Language Abstract of WO91/14673.
English Language Abstract of JP 2000-34262.
English Language Abstract of JP 61-76440.
Chem. Pharm. Bull., 32, p. 4209-4212, (1984).
J. Cellular Physiology, 135, 179-188 (1988).
English Language Abstract of JP 61-22047.
Kagechika, H. et al., J. Med. Chem. 31, vol. 31 (No. 11), 2182-2192 (1988).
Toriumi, Y. et al., J. Org. Chem., vol. 55 (No. 1), 259-263(1990).
Kagechika Hiroyuki
Nagano Hiroo
Jones Dameron L.
Research Foundation Itsuu Laboratory
Toko Pharmaceutical Ind. Co., Ltd.
LandOfFree
Process for the production of crystals of a benzoic acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the production of crystals of a benzoic acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of crystals of a benzoic acid... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3932073