Process for the production of chiral propionic acid derivatives

Details Process for the production of chiral propionic acid derivatives Process for the production of chiral propionic acid derivatives

2008-04-29

2008-04-29

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11811071

ABSTRACT:
The present invention is concerned with a novel process for the preparation of compounds of formula Icomprising catalytic asymmetric hydrogenation of a compound of formula (II)in the presence of a catalyst comprising ruthenium and a chiral diphosphine ligand or comprising rhodium and a chiral diphosphine ligand, wherein R1, R2, R3and R4are as defined in the specification and claims. The compounds of formula I and the corresponding salts and/or esters are pharmaceutically active substances.

REFERENCES:
patent: 6969725 (2005-11-01), Binggeli et al.
patent: WO 00/66572 (2000-11-01), None
patent: WO 02/092084 (2002-11-01), None
Schmidt, U., et al., Synthesis and Enantioselective Hydrogenation of alpha-Acyloxyacrylates, Synthesis, Georg Thieme Verlag Stuttgart, DE, vol. 13, 1994, pp. 1138-1140, XP001204845.
Burk, M.J., et al, Rh-DuPHOS-Catalzed Enantioselective Hydrogenation of Enol Esters, Application to the Synthesis of Highly Enantioenriched alpha-Hydroxy Esters and 1,2-Diols, Journal of the American Chemical Society, American Chemical Society, Washington, DC, US, vol. 120, No. 18, 1998, pp. 4345-4353, XP002315073.

Affiliated with

Also associated with

Rating

Process for the production of chiral propionic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of chiral propionic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of chiral propionic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3945222