Process for the production of cephalosporin derivatives

Details Process for the production of cephalosporin derivatives Process for the production of cephalosporin derivatives

1989-06-29

1990-09-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514206, C07D50138, A61K 31545

Patent

active

049546244

ABSTRACT:
New process for the production of the pentahydrate of ceftazidime of formula ##STR1## characterized in that the ester group of the compound of formula ##STR2## or an acid addition salt thereof, is cleaved by the sole use of aqueous hydrochloric acid, and the resulting ceftazidime is either crystallized directly from the reaction mixture as the pentahydrate by adding a base, or first of all the dihydrochloride of the ceftazidime is isolated by adding acetone and/or ethanol or another anti-solvent which is miscible with water, and this is converted into the pentahydrate by known methods.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4659813 (1987-04-01), Bruning et al.
patent: 4769450 (1988-09-01), Stone et al.

Affiliated with

Also associated with

Rating

Process for the production of cephalosporin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of cephalosporin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of cephalosporin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-443260