Process for the production of cell stimulating agents

Details Process for the production of cell stimulating agents Process for the production of cell stimulating agents

1983-05-19

1986-07-08

Sadowski, David

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210641, 210651, 2041826, B01D 1300

Patent

active

045991766

ABSTRACT:
The invention concerns a process for obtaining cell respiratory stimulating active agents having a molecular weight in the range of about 300 to 8000 Dalton, by defibrination of calves blood, hemolyzing the solution obtained thereby, separating the proteins and substances having a molecular weight of over about 8000 Dalton comprised in the hemolyzed solution by a membrane separation procedure, concentrating the resulting protein- and high molecular weight-freed solution under reduced pressure at a temperature not exceeding 40.degree. C. to a density in the range of 1.10 to 1.15 g/ml at 20.degree. C. and partially separating the inorganic salts from the resulting concentrated solution, wherein the membrane separation procedure employed is a continuous multi-step ultrafiltration procedure employing membranes with a molecular weight exclusion limit of about over 8000 Dalton and the partial separation of the inorganic salts is carried out by electrodialysis with the aid of membranes with a membrane permeability up to a molecular weight of about 300 Dalton.

REFERENCES:
patent: 3746591 (1973-07-01), Banfield
patent: 3972614 (1976-08-01), Johansen et al.
patent: 3973001 (1976-08-01), Jaeger et al.
patent: 4013791 (1977-03-01), Wissmann et al.
patent: 4166948 (1978-09-01), Mittenzwei et al.
patent: 4322275 (1982-03-01), Jain
patent: 4350581 (1981-09-01), Schmoldt et al.
Porter, M. C. et al, "Membrane Ultrafiltration", Chem. Tech., Jan. 1971, pp. 56-63.

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