Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2007-05-21
2011-11-29
Bernhardt, Emily (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C549S399000, C560S140000, C564S316000
Reexamination Certificate
active
08067594
ABSTRACT:
The invention provides a process for producing a compound of formula (I),wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of:(i) reacting a compound of formula (II),wherein OX represents hydroxy or O−M+, in which M+is a cation selected from Li+, Na+and K+, andY is as defined above;with trans-cinnamaldehyde (III),in the presence of a secondary amine compound; then(ii) treating the product of the preceding step with acid to afford the compound of formula (I).The above process may also be used in the production of tolterodine and fesoterodine, which are useful in the treatment of overactive bladder.
REFERENCES:
patent: 5733936 (1998-03-01), Buschmann et al.
patent: 6858650 (2005-02-01), Meese
patent: 2004/0209916 (2004-10-01), Richards
patent: 1254890 (2002-11-01), None
patent: WO 9829402 (1998-07-01), None
patent: 9958478 (1999-11-01), None
patent: 0149649 (2001-07-01), None
Jurd, L. “Synthesis of 4-phenyl-2H-1-benzopyrans”, Journal of Heterocyclic Chemistry, vol. 28, No. 4, 1991, pp. 983-986.
Botteghi, C. et al., “A new efficient route to tolterodine”, Organic Process Research & Development, vol. 6, No. 4, Jul. 2002, pp. 379-383.
Saimoto, et al., “Synthesis of 3,4-Dihydro-2H-Benzopyrans from Phenols and α,β-Unsaturated Carbonyl Compounds”, Heterocycles, vol. 55, 2001, pp. 2051-2054.
Ahman Jens Bertil
Dillon Barry Richard
Pettman Alan John
Bernhardt Emily
Kispert Jennifer A.
Pfizer Inc.
Zanzalari Richard V.
LandOfFree
Process for the production of benzopyran-2-ol derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the production of benzopyran-2-ol derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of benzopyran-2-ol derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4288585