Process for the production of basic substituted alkyl theophylli

Details Process for the production of basic substituted alkyl theophylli Process for the production of basic substituted alkyl theophylli

1977-12-21

1979-04-17

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

424253, C07D47308

Patent

active

041502272

ABSTRACT:
Basic substituted alkyl theophylline derivatives of the formula ##STR1## in which Alk is a straight or branched chain alkylene group with 2 to 4 carbon atoms and R is hydrogen or a methyl group are produced by catalytic hydrogenation of compounds of the formula ##STR2## where the phenolic hydroxyl groups and/or the secondary basic nitrogen atom can contain protective groups using as the solvent a compound of the formula ##STR3## where R', R" and R'" are the same or different and are alkyl groups of 1 to 2 carbon atoms and R' together with R'" can also be an alkylene bridge with 3 to 4 carbon atoms and in a given case the protective groups present are split off.

REFERENCES:
patent: 3398150 (1968-04-01), Klinger et al.
patent: 3728346 (1973-04-01), Klingler

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