Process for the production of base for topical steroids

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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424243, 424362, A61K 3156, A61K 3171

Patent

active

040137929

ABSTRACT:
A clear gel composition containing a topically active anti-inflammatory steroid and a neomycin salt is disclosed. The clear gel composition is prepared by dissolving the steroid in a polyhydroxy alcohol/lower alcohol solvent, a major proportion of the polyhydroxy alcohol solvent being propylene glycol, and adding a hydroxycellulose ingredient; an aqueous solution of the neomycin salt is then added to the steroid formulation and, upon the addition of an alkali metal chloride salt, such as sodium chloride, a clear gel is obtained. The pH may be adjusted to 4-5. The resulting composition is indicated for the relief of corticosteroid-responsive dermatoses.

REFERENCES:
patent: 3485915 (1969-12-01), Gerstein et al.
patent: 3529060 (1970-09-01), Ercoli et al.
patent: 3749773 (1973-07-01), Ninger et al.

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