Process for the production of aqueous dispersions of lipid spher

Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...

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264 41, 424450, 4284022, 436829, A61K 9127, B01J 1302

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active

050212001

ABSTRACT:
A process for producing a dispersion of spherules of a lipid compound encapsulating an aqueous phase includes admixing a water-dispersible lipid compound with an aqueous phase to be encapsulated in the spherules, agitating the resulting mixture to form a lamellar phase, adding a liquid dispersion phase and vigorously shaking the resulting mixture.

REFERENCES:
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patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4416872 (1983-11-01), Alving et al.
patent: 4536324 (1985-08-01), Fujiwara et al.
patent: 4743449 (1988-05-01), Yoshida et al.
Papahadjopoulos et al: "Cochleate Lipid Cylinders: Formation by Fusion of Unilamellar Lipid Vesicles", Biochimica et Biophysica Acta, 394 (1975) 483-491.

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