Process for the production of antibodies

Details Process for the production of antibodies Process for the production of antibodies

1994-11-15

1997-06-17

Ziska, Suzanne E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

800 2, 800DIG1, 800DIG4, 4351723, C12N 1500, A61K 3900

Patent

active

056394578

ABSTRACT:
Process for the production of proteins with antibody activity in which one or several DNA sequences coding for this protein are introduced into the male pronucleus of a fertilized ovum of a pig or rabbit by microinjection, the ova are implanted in the oviduct of a pig or rabbit, the offspring are bred and the protein with antibody activity is isolated from their serum in the usual way whereby the DNA sequences used for the microinjection are free of bacterial foreign sequences, and are preferably used with immunoglobulin promoter and enhancer sequences.

REFERENCES:
patent: 4642334 (1987-02-01), Mone et al.
patent: 4870009 (1989-09-01), Evans et al.
Proceedings of the National Academy of Sciences of the U.S.A., Band 85 No. 9, May 1988, pp. 3130-3134.
Brem et al, Production of transgenic mice, rabbits and pigs by microinjection into pronuclei, Zuchthygiene, Jan. 20, 1985.
Hammer et al, Nature, Production of transgenic rabbits, sheep and pigs by microinjection, vol. 315, Jun. 20, 1985.
Bruggemann et al J. Exp. Med 166: 1351, 1987.
Weidle et al Gene 98: 185, 1991.
Hanner et al Nature 315: 680, 1985.
Kocks et al PNAS 85: 8206, 1988.
Jaenisch et al Science 240: 1470, 1988.
Lenz et al Gene 87: 213, 1990.

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