Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1986-06-20
1989-03-21
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
435 68, 4351722, 43524027, A61K 39395, C12P 2100, C12N 1500
Patent
active
048141690
ABSTRACT:
The present invention relates to a process for the production of anti-human protein antibody, comprising induction of the antibody production in non-human warm-blooded animal cells capable of producing said antibody by injecting into a non-human warm-blooded animal a human protein-saccharide conjugate, obtained by covalent attachment of a human protein with a saccharide, and harvesting the resulting anti-human protein antibody. The antibody, prepared according to the invention, contains an extremely higher amount of immunoglobulin G than that obtained by conventional method while it contains slight or substantially no immunoglobulin E. Therefore, the antibody can be used advantageously for diagnostic, prophylactic or therapeutic administration in the prevention and treatment of human diseases.
REFERENCES:
patent: 4172124 (1979-10-01), Kaprowski et al.
patent: 4196265 (1980-04-01), Koprowski
patent: 4364935 (1982-12-01), Kung et al.
patent: 4372883 (1983-02-01), Matuhashi et al.
NATURE, vol. 273, 22 Jun. 1978, pp. 666, 668, Chesham, Bucks, GB; M. M. Trucco et al: "Monoclonal Antibodies . . . ", p. 666, colonne de droite.
Koyama Shunsaku
Mitsuhashi Masakazu
Hazel Blondel
Kabushika Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
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