Process for the production of an N-protected-L-.alpha.-aspartyl-

Details Process for the production of an N-protected-L-.alpha.-aspartyl- Process for the production of an N-protected-L-.alpha.-aspartyl-

1987-10-13

1988-12-06

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

530801, C07C 9900

Patent

active

047897589

ABSTRACT:
A process is described for the synthesis of N-protected-L-.alpha.-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R.sub.1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R.sub.2, where R.sub.1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R.sub.2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.

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patent: 3933781 (1976-01-01), Bachman et al.
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patent: 4017472 (1977-04-01), Farkas et al.
patent: 4333872 (1982-06-01), Sampathkumar et al.
patent: 4507231 (1985-03-01), Gourbault
patent: 4539147 (1985-09-01), Filippini et al.

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