Process for the production of an infusion or dialysis solution c

Details Process for the production of an infusion or dialysis solution c Process for the production of an infusion or dialysis solution c

1997-08-01

1999-08-31

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Elemental fluorine or fluorine compound

424686, 514 23, 514557, A61K 3314, A61K 3310, A61K 3370, A61K 3119, A61K 3170

Patent

active

059451297

ABSTRACT:
The invention relates to a process for the production of an infusion or dialysis solution containing bicarbonate and having a physiologically tolerable pH. In order to retain a solution with a stable physiologically tolerable pH even after heat treatment for sterilization, according to the invention, at least 2 mmol/L of at least one carboxylic acid ester is introduced into the solution beforehand. The solution is subjected to heat treatment above 100.degree. C., so that the carboxylic acid ester decomposes almost completely into carboxylic acid and alcohol. The invention further relates to a use of the process according to the invention for the production of a solution for peritoneal dialysis and a medicinal infusion or dialysis solution.

REFERENCES:
patent: 4489535 (1984-12-01), Veltman
Bronswijk et al., "Cytotoxic Effects of Commercial Continuous Ambulatory Peritoneal Dialysis (CAPD) Fluids and of Bacterial Exoproducts on Human Mesothelial Cells In Vitro," Peritoneal Dialysis International, vol. 9, 1989, pp. 197-202.
Witowski et al., "Effect of lactate-buffered peritoneal dialysis fluids on human peritoneal mesothelial cell interleukin-6 and prostaglandin synthesis," Kidney International, vol. 46, 1994, pp. 282-293.
Schambye et al., "The Cytotoxicity of Continuous Ambulatory Peritoneal Dialysis Solutions with Different Bicarbonate/Lactate Ratios," Peritoneal Dialysis International, vol. 13, Supplement 2, 1993, pp. S116-S118.

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