Process for the production of an adhesive plaster

Details Process for the production of an adhesive plaster Process for the production of an adhesive plaster

1987-11-06

1989-07-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

421449, 421447, A61F 1302

Patent

active

048449032

ABSTRACT:
The process results in an adhesive plaster for the transdermal adminstration of pharmaceutical, in particular heat-sensitive, active substances, composed of an adhesive layer, a backing layer, a matrix layer containing the active substances, and a protective layer. The flux of active substance release is controlled by its diffusion from the matrix layer. The latter is produced by the hot melt method, by mixing an ethylene/vinyl acetate copolymer and an involatile, hydrophobic excipient which is miscible with the latter, is compatible with the active substance and is tolerated by the skin, for example isopropyl myristate or a triglyceride, at the melting point of the mixture, and incorporation therein of a solution or dispersion of the active substance in a small amount of the same excipient.

REFERENCES:
patent: 3598122 (1971-08-01), Zaffaroni
patent: 3731683 (1973-05-01), Zaffaroni
patent: 3742951 (1973-07-01), Zaffaroni
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4272507 (1981-06-01), Figala
patent: 4466953 (1984-08-01), Keith et al.
patent: 4573995 (1986-03-01), Chen
patent: 4585452 (1986-04-01), Sablotsky
patent: 4605548 (1986-08-01), Ushiyama et al.

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