Process for the production of amphotericin-B inhibiting producti

Details Process for the production of amphotericin-B inhibiting producti Process for the production of amphotericin-B inhibiting producti

1998-05-22

2000-10-17

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435244, 435119, 435170, C12P 1962

Patent

active

061329932

ABSTRACT:
Methods are provided for improving the microbial production of amphotericin B by the selective inhibition of amphotericin A by means of protein synthesis inhibitors.

REFERENCES:
patent: 2908611 (1959-10-01), Dutcher et al.
patent: 2908612 (1959-10-01), Dutcher et al.
Gold, W., et al., "Amphotericins A and B, Antifungal Antiobiotics Produced by a Streptomycete, I. In Vitro Studies", Antibiotics Annual 1955-1956, 576-578.
Vandeputte, J., et al. "Amphotericins A and B, Antifungal Antibiotics Produced by a Streptomycete, II. The Isolation and Properties of the Crystalline Amphotericins", Antibiotics Annual 1955-1956, pp. 587-591.
Mechlinski, W., et al., "Structure and Absolute Configuration of the Polyene Macrolide Antibiotic Amphotericin B", Tethrahdron Letters, 1970, No. 44, pp. 3873-3876.
Ganis, P., et al., "Polyene Macrolide Antibiotic Amphotericin B. Crystal Structure of the N-Iodoacetyl Derivative", The Journal of the American Chemical Society, 1971, 93:18, pp. 4560-4564.
Linke, H., et al., Production of Amphotericin B-.sup.14 C By Streptomyces Nodusus Fermentation, and Preparation of the Amphotericin B-.sup.14 C Methyl-Ester, The Journal of Antibiotics, 1974, pp. 155-160.
Sowinski, P., et al., "The Structure of Amphotericin A. I. Mass Spectrometric Analysis of Dodecahydroamphotericin A", The Journal of Antibiotics, 1985, vol. XXXVII No. 2, pp. 169-174.
Sowinski, P., et al., "The Structure of Amphotericin A. II. The Complete Structure of the Antibiotic", The Journal of Antibiotics, 1985, vol. XXXVIII, No. 2, pp. 175-180.
Liu, Y., Biosynthetic Studies of Amphotericins, Candicidin, and Nystatin by Means of Mutation, Proc. Natl. Sci., Counc, ROC, 1984, vol. 8, No. 2, pp. 182-186.
Perlman, D., et al., Preparation of Amphotericin B-.sup.14 C, Biotechnology and Bioengineering, vol. VII, pp. 133-137.
Trejo, W.H., et al., Streptomyces Nodosus Sp. N., The Amphotericin-Producing Organism, Journal of Bacteriology, 1963, vol. 85, pp. 436-439.
Landini, P., et al., Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding artibiotics MDL 62,879 and efrotomycin, Biochem. J., 1992, 283(3), pp. 649-652.
Rahman, M.A., et al., Antibacterial Activity and Inhibition of Protein Synthesis in Escherichia coli by Antisene DNA Analogs, Antisense Research and Development, 1991, 1(4), pp. 319-327.
Shabas et al, Antibiotiki (MOSC), 22(5), 1977 p. 396-400.

Affiliated with

Also associated with

Rating

Process for the production of amphotericin-B inhibiting producti does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of amphotericin-B inhibiting producti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of amphotericin-B inhibiting producti will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-467224