Process for the production of alpha-6-deoxytetracyclines and hyd

Details Process for the production of alpha-6-deoxytetracyclines and hyd Process for the production of alpha-6-deoxytetracyclines and hyd

1988-10-28

1990-02-20

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Tetracyclo naphthacene configured ring system having at...

C07C10319

Patent

active

049024477

ABSTRACT:
A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C.sub.1 -C.sub.4 alkyl; and X is chloro, bromo or iodo. This compound is particularly useful as a homogeneous hydrogenation catalyst in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.

REFERENCES:
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patent: 3962131 (1976-06-01), Faubl et al.
patent: 4031137 (1977-06-01), Schmitt, Jr. et al.
patent: 4550096 (1985-10-01), Page et al.
patent: 4597904 (1986-07-01), Page

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