Process for the production of alpha-6-deoxytetracyclines

Details Process for the production of alpha-6-deoxytetracyclines Process for the production of alpha-6-deoxytetracyclines

1990-07-12

1991-09-17

Ivy, C. Warren

Gas separation

552207, C07C10375

Patent

active

050496832

ABSTRACT:
A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods.

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