Process for the production of alpha-6-deoxytetracyclines

Details Process for the production of alpha-6-deoxytetracyclines Process for the production of alpha-6-deoxytetracyclines

1988-10-28

1990-11-27

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Tetracyclo naphthacene configured ring system having at...

C07C23748

Patent

active

049737198

ABSTRACT:
A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline, in the presence of hydriodotetrakis (triphenylphosphine) rhodium (I) as a homogenous hydrogenation catalyst. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.

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