Process for the production of alkoxycarbonyldipeptides intermedi

Details Process for the production of alkoxycarbonyldipeptides intermedi Process for the production of alkoxycarbonyldipeptides intermedi

1999-06-18

2000-12-26

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26344

Patent

active

061662178

ABSTRACT:
Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.

REFERENCES:
T.J. Blacklock et al., "Large Scale N-Carboxyanhydride Preparation Of Ala-Pro And N .epsilon.--(TFA) --LYS-PRO: Synthesis of Ace Inhibitors", Peptides: Structure and Function: Proceedings of the Nineth American Peptide Symposium 787-790, 1985.
Wu et al., Synthesis of . . . (Lisinopril), Journal of Pharmaceutical Sciences, 74(3), p. 352-353, Mar. 1985.

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