Process for the production of alkoxycarbonyl-dipeptides intermed

Details Process for the production of alkoxycarbonyl-dipeptides intermed Process for the production of alkoxycarbonyl-dipeptides intermed

1999-01-25

2000-02-29

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548227, C07D20708, C07D26304

Patent

active

060311126

ABSTRACT:
Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.

REFERENCES:
Wu et al., Synthesis of . . . (Iisinopril), Journal of Pharmaceutical Sciences, 74(3), pp. 352-354, Dec. 1985.

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