Process for the production of a transdermal therapeutic system c

Details Process for the production of a transdermal therapeutic system c Process for the production of a transdermal therapeutic system c

1998-08-14

1999-12-07

Stright, Ronald

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61L 1516, A61F 1300

Patent

active

05997897&

ABSTRACT:
This invention relates to a process for the production of a transdermal therapeutic system containing the active substance 17-.beta.-estradiol and optionally further active substances having a laminated structure positioned on a backing layer which is essentially impermeable to active substance and moisture, one or more matrix layers and optionally an adhesive layer, characterized in that at least one of the matrix layers or the adhesive layer contains anhydrous 17-.beta.-estradiol in crystalline form.

REFERENCES:
patent: 3854480 (1974-12-01), Zaffaroni
patent: 4863738 (1989-09-01), Taskovich
T. Higuchi, "Physical Chemical Analysis . . . " J.Soc.Cosmetic Chem. 11, pp. 85-97 (1960).
Busetta et Michael Hospital "Structure Cristalline . . . " Acta Cryst. 1972, B28, pp. 560-567.
Kuhnert-Brandstatter and H. Winkler (1976) Scientia Pharmaceutica 44 (3) pp. 177-190.

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