Package making – Methods – Forming or partial forming a receptacle and subsequent filling
Patent
1996-02-09
1998-09-08
Culver, Horace M.
Package making
Methods
Forming or partial forming a receptacle and subsequent filling
53559, B65B 4710, B65B 302, B65B 4354
Patent
active
058028161
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
a) Field of the Invention
The invention is directed to a process and a device for the production of a specimen carrier having a plurality of individual specimen locations for receiving specimens and to the specimen carrier itself.
b) Description of the Related Art
Specimen carriers with a plurality of specimen locations are used in blood group serology, for antibiotics test series, and further for laboratory work requiring geometric dilution series. Specimen carriers of this kind, also called microtitration plates, such as those known from DE GM 88 14 762.2 are designed as injection-molded articles formed of a transparent plastic with a plurality of depressions serving as specimen locations for receiving specimens. The specimens are placed in the individual specimen locations manually or automatically by pipetting and are freeze-dried or volatilized.
The production of the known specimen carriers, which are also frequently constructed in multiple parts, requires great precision in carrying out the injection molding process and a careful final inspection since the specimen carriers are precision parts. Moreover, elaborate sanitary measures are required for production and storage in order to avoid contaminating the specimen carriers and to prevent errors in subsequent series of measurements.
Further, the measurement of C.sup.14 -tagged specimens by means of radioluminography image plates has proven extremely difficult with the known specimen carriers. The C.sup.14 .beta.-radiation to be measured does not penetrate the base or wall of known specimen carriers. Therefore, the image plate can only be exposed at the open top. The disadvantage in such a process consists in that the specimen locations which are open at the top are covered by the image plate and measurements may be falsified as a result of reactions between the image plate and the specimen.
In particular, it has proven extremely difficult to measure C.sup.14 -tagged specimens by means of radioluminography image plates in the known specimen carriers when the specimen volume is small. In microbore HPLC (High Pressure Liquid Chromatography), specimen volumes are approximately 1-50 microliters or 1-100 nanoliters in capillary electrophoresis. These small quantities make exposure of the image plate at the open top considerably more difficult.
OBJECT AND SUMMARY OF THE INVENTION
The present invention has a primary object of providing, by means of a more economical process, an easily manageable specimen carrier for the measurement of tagged specimens, especially also those having a small specimen volume, in which the detection sensitivity of C.sup.14 .beta.-radiation is substantially improved and is directed to the process and a device for producing the specimen carrier as well as the specimen carrier itself.
Costly molds for injection-molded articles are eliminated by means of the process according to the invention for producing a specimen carrier for carrying out the object in which carrying the specimens;
Further, a commercially obtainable sheet is used in an economical manner as starting material for the production of a specimen carrier which is closed on all sides so that its use cannot result in reactions between the specimen material and the environment which lead to falsified measurements. Suitable selection of the dimensions of the depressions to be produced enables individual and flexible adaptation to the measurements to be taken.
These depressions are advantageously produced in that the sheet is brought into contact with a support having voids or negative molds of the depressions, in that the negative molds are subsequently evacuated, the depressions being formed by the air pressure in the sheet in conformity to the negative molds. When commercially available thin sheets are used, these sheets lie flat against the surface of the negative molds after evacuation is effected so that individual specimen locations of exactly defined dimensions are formed. According to the invention, after the depressions are produced,
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Culver Horace M.
Raytest Isotopenmessgeraete GmbH
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