Process for the production of a novel endothelin antagonist

Details Process for the production of a novel endothelin antagonist Process for the production of a novel endothelin antagonist

1993-03-11

1994-10-04

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435121, 435911, C07D207273

Patent

active

053528000

ABSTRACT:
Fermentation processes for the production of a compound of the Structural Formula I ##STR1## The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.

REFERENCES:
patent: 5082838 (1992-01-01), Naka et al.
patent: 5114918 (1992-05-01), Ishikawa et al.
patent: 5187195 (1993-02-01), Oohata et al.

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