Process for the production of a nanoemulsion of oil particles in

Details Process for the production of a nanoemulsion of oil particles in Process for the production of a nanoemulsion of oil particles in

1990-06-21

1992-10-06

Lovering, Richard D.

Compositions

Preservative agents

Anti-corrosion

252314, 424455, 514938, 4352403, 43524031, B01J 1300

Patent

active

051529238

ABSTRACT:
An aqueous phase, an oil of a triglyceride or fatty acid ester, and, per part by weight of oil 0.05 to 0.4 part by weight of an amphoteric emulsifier are mixed together and processed in a high-pressure homogenizer into a nanoemulsion of less than 200 nm sized oil particles. The emulsifier, exhibiting in the aqueous phase a lamellar liquid-crystalline structure, is preferably a glycerophosphatide of the formula: ##STR1## wherein, R.sub.1 and R.sub.2 mean acyloxy and/or alkyl or alkenyl ether. R.sub.3 is a tri-lower-alkyl ammonio or amino-substituted lower alkyl. The resultant nanoemulsion is stable for a period of several months and does not contain any toxic emulsifier materials. Therefore, it can be advantageously utilized as a vehicle for active agents, for example medicines and/or cosmetic ingredients.

REFERENCES:
patent: 4794000 (1988-12-01), Ecanow
patent: 5021381 (1991-06-01), Burroway et al.
Biochemstry, by L. Stryer, W. H. Freeman and Company, New York, New York, 1988, pp. 288-290.

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