Process for the production of a dipeptide, a polypeptide or a pr

Details Process for the production of a dipeptide, a polypeptide or a pr Process for the production of a dipeptide, a polypeptide or a pr

1982-05-25

1984-04-03

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044406762

ABSTRACT:
The invention lies in the field of peptide and protein synthesis. It related to the use of pentaco-ordinate phosphoranes, such as 2-hydro-2,2'-spirobis(1,3,2-benzodioxaphosphole) as coupling agents in a process for the production of a dipeptide, a polypeptide or a protein. Coupling is preferably effected in the presence of both a tertiary amine and a solvent and advantageously in the additional presence of an oxazalone formation suppressant, such as N-hydroxysuccinimide.

REFERENCES:
Cadogan, et al., J. Chem. Soc. Chem. Commun., (1982), 298-299.

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