Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo
Patent
1995-06-02
1998-03-24
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-5-aza-bicyclo
435 46, 435 51, 4352545, 540218, C12P 3702, C12P 3502, C07D50100
Patent
active
057311650
ABSTRACT:
An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.
REFERENCES:
Baldwin et al., "The Enzymatic Ring Expansion of Penicillins To Cephalosporins: Side chain Specificity," Tetrahedron 43:3009-3017 (1987).
Cantwell et al., "Cloning and expression of a hybrid Streptomyces clavuligerus ce.function.E gene in Penicillium chrysogenum," Curr Genet 17:213-221 (1990).
Yeh et al., "Biochemical characterization and Evolutionary Implication of .beta.-Lactam Expandase/Hydroxylase, Expandase and Hydroxylase" 50 Years of Penicillin Application (H. Kleinkauf and H. Von Dohren, Editors) pp. 209-210 (1991).
Aharonowitz, Y., et al. (1992) Ann. Rev. Microbiol. 46:461-495.
Baldwin, et al. (1988) Natural Product Reports 5(2):129-145.
Cantwell, et al. (1992) Proc. R. Soc. Lond. B. 248:283-289.
Coque, et al. (1993) Mol. Gen. Genet. 236:453-458.
Cortes, et al. (1987) J. Gen. Microbiol. 133:3166-3174.
Crawford, et al. (1995) Bio/Technology 13:58-61.
Ingolia, et al. (1989) Med. Res. Rev. 9:245-264.
Maeda, et al. (1995) Enzyme and Microbial Technology 17:231-234.
Bovenberg Roelof Ary Lans
Koekman Bertus Pieter
Schipper Dirk
Vollebregt Adrianus Wilhelmus
Gist-Brocades B.V.
Mytelka Daniel
Wax Robert A.
LandOfFree
Process for the production of 7-ADCA via expandase activity on p does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the production of 7-ADCA via expandase activity on p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of 7-ADCA via expandase activity on p will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2287960