Process for the production of 6-substituted 4-methyl-2-pyridones

Details Process for the production of 6-substituted 4-methyl-2-pyridones Process for the production of 6-substituted 4-methyl-2-pyridones

1979-01-11

1980-05-27

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21364

Patent

active

042051746

ABSTRACT:
Process for the production of 6-substituted-4-methyl-2-pyridones having the formula: ##STR1## wherein R is a branched or unbranched alkyl group, a halogenated branched or unbranched alkyl group or a substituted or unsubstituted aryl group. Senecioic acid amide having the formula: ##STR2## is reacted in a solvent at an elevated temperature in the presence of a Lewis acid (as a catalyst) with an acyl chloride having the formula: ##STR3## wherein R has the same meaning as above. The reaction mixture is subsequently placed in an aqueous phase for hydrolysis. The 6-substituted-4-methyl-2-pyridone is separated by extraction through the buffering of the reaction mixture at a pH of 4 to 5.

REFERENCES:
patent: 2516673 (1950-07-01), Bruce
patent: 3711488 (1973-01-01), Bayer
patent: 3754088 (1973-08-01), Witzel
patent: 3926935 (1975-12-01), Rogers et al.
Chem. Abs., vol. 73 (1970) 120508a, abstracting South African Patent No. 69/06,039.
I. Alkonyi, Report 98, (1965) pp. 3099-3101.
Morrison, Robert T. et al., "Organic Chemistry", Allyn and Bacon, Inc. Boston (1956) pp. 23-24.
Robertson, G. Ross et al., "Laboratory Practice of Organic Chemistry", 4th Ed., The Macilllan Company, New York, (1962) p. 272.

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