Process for the production of 6-hydroxynicotinic acid

Details Process for the production of 6-hydroxynicotinic acid Process for the production of 6-hydroxynicotinic acid

1985-02-14

1992-01-21

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435824, 435832, 435874, 435877, 4352521, 4352525, 4352533, C12P 1712, C12N 120, H01R 1324, H01R 448

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050827774

ABSTRACT:
Process for the production of 6-hydroxynicotinic acid from nicotinic acid. The hydroxylation is carried out enzymatically in the presence of a microorganism of the species Pseudomonas, Bacillus or Achromobacter, for example, Achromobacter xylosoxydans. Preferably the enzymatic hydroxylation is carried out at 20.degree. to 40.degree. C. and a pH of 5.5 to 9.0 under aerobic conditions. Also, preferably a 0.1 percent by weight solution up to a saturated (preferably a 0.5 to 10 percent by weight) nicotine acid solution is used.

REFERENCES:
patent: 4038993 (1977-08-01), Geiss et al.
Briaucourt et al., J. Chim. Ther. (1973), 8 (2), pp. 226-232.
Allison, M. J. C., Biol. Chem. (1943), 147, p. 785.
Behrman, E. J., and Stanier, R. V., J. Biol. Chem. (1957) 228, p. 923.
Hunt, A. L., Biochem. J. (1958), 72, pp. 1-7.
Ensign and Rittenberg, J. Biol. Chem., 239 (1964), pp. 2285-2291.

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