Process for the production of (.+-.)-4-oxo-1,2,3,6,7,11b-hexahyd

Details Process for the production of (.+-.)-4-oxo-1,2,3,6,7,11b-hexahyd Process for the production of (.+-.)-4-oxo-1,2,3,6,7,11b-hexahyd

1983-07-08

1985-02-05

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544385, 544406, C07D47104, C07D24108

Patent

active

044979525

ABSTRACT:
This invention discloses a process for the preparation of (.+-.)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives which comprises conducting an intramolecular cyclization reaction of the compounds of formulas II III in an acid medium. ##STR1##

REFERENCES:
patent: 2763652 (1956-09-01), Sapir et al.
patent: 2927114 (1960-03-01), Izzo et al.
patent: 3502679 (1970-03-01), Honlihan et al.
patent: 3993760 (1976-11-01), Pohlke et al.
Hubert et al., Tetrahedron Letters 44, 4493-4496 (1972).
Lal et al., Chem. Abst. 96, 35289 (1982).

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