Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-ace

Details Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-ace Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-ace

1991-11-13

1994-01-04

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548543, C07D20738, C07D207273

Patent

active

052761649

ABSTRACT:
Process for the production of 4-hydroxy-2-oxoyrrolidin-1-yl-acetamide, a cerebrally active pharmaceutical agent. A 4-halo-3-alkoxy-butenoic acid ester is reacted with glycine to new intermediate products of the formula: ##STR1## There is further by acid hydrolysis of the alkoxy group, subsequent hydrogenation, esterification of the carboxyl function and finally conversion to the end product by reaction with ammonia.

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