Process for the production of 4-androstene-3,17-dione and 1,4-an

Details Process for the production of 4-androstene-3,17-dione and 1,4-an Process for the production of 4-androstene-3,17-dione and 1,4-an

1994-06-28

1996-05-14

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435865, 435863, 4352531, 4352532, C12P 3316

Patent

active

055166490

ABSTRACT:
A process for the production of 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione of the general formula ##STR1## wherein . . . . . symbolizes a single bond or a double bond, characterized in that ergosterol ##STR2## is fermented with a culture of a microorganism strain capable of side-chain degradation of sterols.

REFERENCES:
patent: 3684657 (1972-08-01), Kraychy
patent: 3759791 (1973-09-01), Marsheck
patent: 4293645 (1981-10-01), Wovcha et al.
Pavia et al, "Introduction to Organic Laboratory Techniques", 1976, pp. 14-15.
Ambrus et al., Experentia, vol. 24, p. 432, 1968.
Wix et al., Steroids, vol. 11, pp. 401-413, 1968.
Nagasawa et al., Agr. Biol. Chem., vol. 34, No. 5, pp. 798-800, 1970.
Goodfellow et al., The Biol of the Actinomycetes, pp. 40-44, 74-75, 1986.
Marsheck et al., Applied Micro. Jan. 1972, pp. 72-77.
Goodfellow et al, The Biology of the Actinomycetes, 1984, Academic Press.

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