Process for the production of 4-aminobutyramide hydrochloride

Details Process for the production of 4-aminobutyramide hydrochloride Process for the production of 4-aminobutyramide hydrochloride

1980-11-18

1982-03-30

Demers, Arthur P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564124, C07C10200

Patent

active

043225527

ABSTRACT:
4-aminobutyramide hydrochloride is produced by hydrogenation of 3-cyanopropionamide in the presence of a solvent inert under the reaction conditions, a noble metal catalyst and hydrogen chloride at a temperature between 5.degree. and 80.degree. C. The hydrochloride can be easily converted into 4-aminobutyramide which as such or in the form of derivatives has significance as a neurotransmitter.

REFERENCES:
patent: 3117162 (1964-01-01), Rylander et al.
patent: 4003933 (1977-01-01), Drake
patent: 4137267 (1979-01-01), Reid et al.
Wagner et al., Synthetic Organic Chemistry, John Wiley & Sons, N.Y., N.Y., 1955, p. 660.

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