Process for the production of 4-amino-1-hydroxybutylidene-1,1-bi

Details Process for the production of 4-amino-1-hydroxybutylidene-1,1-bi Process for the production of 4-amino-1-hydroxybutylidene-1,1-bi

1998-02-06

1999-06-01

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

562 10, C07F 930

Patent

active

059089598

ABSTRACT:
A process is provided for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises of:

REFERENCES:
patent: 4157364 (1979-06-01), Buckman
patent: 4304734 (1981-12-01), Jary
patent: 4407761 (1983-10-01), Blum et al.
patent: 5019651 (1991-05-01), Kieczykowski
patent: 5510517 (1996-04-01), Dauer
Kieczykowski et al., "Preparation of (4-Amino-1-Hydroxybutylidene)bisphosphonic Acid Sodium Salt, MK-217 (Alendronate Sodium). An Improved Procedure for the Preparation of 1-Hydroxy-1,1-bisphosphonic Acids", J. Org. Chem., 1995, vol. 60, pp. 8310-8312.

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