Process for the production of 4-alkylpyrimidine

Details Process for the production of 4-alkylpyrimidine Process for the production of 4-alkylpyrimidine

2007-02-20

2007-02-20

Rao, Deepak (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

active

10778254

ABSTRACT:
4-alkylpyrimidine is produced by reacting formamide with a formyl methyl alkyl ketone diacetal without the addition of water at a temperature that allows removal of the 4-alkylpyrimidine from the reaction mixture by distillation. The process is readily applicable on an industrial scale and succeeds without the addition of water or ammonium chloride as a catalyst and permits the production of 4-alkylpyrimidine in good yields and excellent purities without time-consuming extraction steps.

REFERENCES:
patent: 2004/0044209 (2004-03-01), Guthner et al.
patent: 100 02 835 (2001-12-01), None
patent: 49-124081 (1974-11-01), None
patent: 8-198858 (1996-08-01), None
H. Bredereck, et al., Angew. Chem., vol. 68, No. 4, pp. 151-152, “Neue Pyrimidin-Synthese Aus β-Dicarbonyl-Verbindungen Und Formamid”, 1956.
H. Bredereck, et al., Chemische Berichte, 90, pp. XXXIX-XIII and 942-952, “Eine Neue Pyrimidin-Synthese2”, 1957.
H. Bredereck, J. Wiley and Sons, Organic Syntheses, Collective vol. 5, pp. xi-xiv, 794-796, “4-Methylpyrimidine”, 1973.

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