Process for the production of 4,5,6,7-tetrahydrothieno-[3,2-c]-p

Details Process for the production of 4,5,6,7-tetrahydrothieno-[3,2-c]-p Process for the production of 4,5,6,7-tetrahydrothieno-[3,2-c]-p

1990-05-02

1991-02-05

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546242, C07C21122, C07C21144

Patent

active

049906186

ABSTRACT:
The following intermediate compounds, namely, 4-Oxo-3-(2-propenyl)-piperidine-3-carboxylic acid ester of the formula: ##STR1## wherein R is hydrogen, a formyl group, an acetyl group or a benzoyl group or is a benzyl group, whose aromatic ring optionally is ring-substituted by at least one halogen atom, and R.sub.1 is an alkyl group with 1 to 4 C atoms.
4-Oxo-3-(2-propenyl)-piperidine of the formula: ##STR2## wherein R is hydrogen, a formyl group, and acetyl group or a benzoyl group or is a benzyl group, whose aromatic ring optionally is ring-substituted by at least one halogen atom.

REFERENCES:
"Ticlopidine: A Review of its Pharmacodynamic and Pharmacolcinetic Properties, and Therapeutic Efficacy in Platelet--Dependent Disease States", by Emmanuel Saltied and Alan Ward, Drugs, vol. 34, 1987, pp. 222-262.
"Thiophene Isosters of Isoquinoline", by Salo Gronowitz and Elina Sandberg, Arkiv for Khemi, vol. 32, No. 19, (1971), pp. 217-227.
"Piperidine Derivatives. XV. The Preparation of 1--Benzoyl--3--Carbethoxy--4--Piperidene. A Synthesis of Guvaeine", S. M. McElwain & Gilbert Strole, Jour. of Am. Chem. Soc., vol. 68, Jan.--Jun. 1946, pp. 1049 to 1053.
"Synthese Des Thienopyridines", by F. Eloy and A. Deryckere, Bulletin Des Societes Chemiques Belges, vol. 79, (1970), Mai, Juin Issue, pp. 301-311.

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