Process for the production of 3-oxoglutaric acid

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2604654, 260483, 260484P, 260537R, 260544K, C07C 5912

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active

039637751

ABSTRACT:
A feasible process for the production of 3-oxoglutaric acid is disclosed wherein ketene and phosgene are reacted in a molar ratio of ketene to phosgene of less than 2 in an organic solvent possessing a dielectric constant at 20.degree.C between 2 and 22 and reacting the resulting product with a Zerewitinoff active hydrogen compound.
A method for the production of citric acid is also disclosed wherein ketene and phosgene are reacted in a molar ratio of the former to the latter of less than 2 in an organic solvent having a dielectric constant of from 2 to 22 at 20.degree.C, reacting the resulting product with an aliphatic alcohol having 1 to 4 carbon atoms to form an acetone dicarboxylic dialkyl ester which in turn is subjected to a cyanohydrin synthesis. The cyanohydrin is then hydrolyzed to form citric acid which is then isolated.

REFERENCES:
patent: 3773821 (1973-11-01), Broussard
patent: 3798266 (1974-03-01), Bottaccio et al.

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