Process for the production of 3'-deoxykanamycin A and intermedia

Details Process for the production of 3'-deoxykanamycin A and intermedia Process for the production of 3'-deoxykanamycin A and intermedia

1981-04-21

1982-11-16

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 137, 424180, A61K 3171, C07H 1522

Patent

active

043595723

ABSTRACT:
3'-Deoxykanamycin A useful as an antibacterial agent can be produced by a new process comprising reacting a 2',2"-di-O-acylated-3'-O-sulfonylated-tetra-N-protected derivative of kanamycin A with a base such as alkali metal alcoholate in a lower alkanol to effect 2',3'- and 3',4'-epoxidation and concurrently removal of the 2'- and 2"-acyl groups, reducing the resultant N-protected 2',3'-anhydro-3'-epi derivative and 3',4'-anhydro-3'-epi derivative of kanamycin A either with hydrogen in the presence of a known hydrogenation catalyst or with sodium borohydride to afford the corresponding N-protected 3'-deoxygenated derivative of kanamycin A and then removing the residual amino-protecting groups therefrom to give 3'-deoxykanamycin A.

REFERENCES:
patent: 4060682 (1977-11-01), Umezawa et al.
patent: 4078138 (1978-03-01), Akita et al.
patent: 4195170 (1980-03-01), Umezawa et al.

Affiliated with

Also associated with

Rating

Process for the production of 3'-deoxykanamycin A and intermedia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of 3'-deoxykanamycin A and intermedia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of 3'-deoxykanamycin A and intermedia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1436651