Process for the production of 2-fluoropurine derivatives

Details Process for the production of 2-fluoropurine derivatives Process for the production of 2-fluoropurine derivatives

1995-06-05

1997-12-09

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2671, 536 273, C07H 100, C07H 19167, C07H 19173

Patent

active

056962550

ABSTRACT:
This invention relates to a process for the production of 2-fluoropurine derivatives from 2-aminopurine derivatives, which are reacted in HF/pyridine or HF/pyridine/H.sub.2 O in the presence of a nitrite.

REFERENCES:
patent: 3983104 (1976-09-01), Vorbruggen
patent: 4090021 (1978-05-01), Vorbruggen
Montgomery et al., J. Am. Chem. Soc., 82:463-468 (Jan. 20, 1960).
Montgomery et al., J. Med. Chem., 12:498-504 (May 1969).
Robins et al., Can. J. Chem., 59:2601-2607 (1981).
Robins et al., Can. J. Chem., 59:2608-2611 (1981).
Vorbruggen et al., Liebigs Ann. Chem., pp. 745-761 (1976).
Montgomery et al., J. Org. Chem., 33:432-434 (1968).
Lopez, Letters in Chemical and Engineering News, p. 2 (Dec. 21, 1992).

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