Process for the production of 2-alkyl or 2-cycloalkyl-4-methyl-6

Details Process for the production of 2-alkyl or 2-cycloalkyl-4-methyl-6 Process for the production of 2-alkyl or 2-cycloalkyl-4-methyl-6

1976-08-23

1977-04-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260557R, 260561R, C07D23934

Patent

active

040187713

ABSTRACT:
Production of 2-alkyl or 2-cycloalkyl-4-methyl-6-hydroxy pyrimidines by first reacting diketene and lower alkanoic or cycloalkanoic acid amides in the presence of catalytic amounts of Lewis bases or Lewis or Bronsted acids, followed by treating the N-acetoacetyl (lower) alkanoic or cycloalkanoic acid amide intermediates with ammonia in the presence of acid catalysts.

REFERENCES:
patent: 3050523 (1962-08-01), Erner et al.
Brown et al., "The Pyrimidines" (1962) p. 228.

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