Process for the production of 2,3-dichloro-5-acetylpyridine

Details Process for the production of 2,3-dichloro-5-acetylpyridine Process for the production of 2,3-dichloro-5-acetylpyridine

1991-03-12

1993-06-22

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21170

Patent

active

052217485

ABSTRACT:
Process for the production of 2,3-dichloro-5-acetylpyridine by reaction of a 5,6-dichloronicotinic acid halide with a methyl magnesium halide in an inert organic diluent. The reaction is performed in the presence of a Cu/Cu halide as the catalyst.

REFERENCES:
patent: 4358455 (1982-11-01), Atkinson et al.
patent: 4927938 (1990-05-01), Lindel et al.
patent: 5051513 (1991-04-01), Jelich
Fieser, Louis F., et al., "Reagents For Organic Synthesis", John Wiley and Sons, Inc., vol. 1, (1967), pp. 167-169.

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